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Spiegelman planned to draw Maus in such a manner, but after initial sketches he decided to use a pared-down style, one little removed from his pencil sketches, which he found more direct and immediate.
Characters are rendered in a minimalist way: animal heads with dots for eyes and slashes for eyebrows and mouths, sitting on humanoid bodies.
Spiegelman wanted the artwork to have a diary feel to it, and so drew the pages on stationery with a fountain pen and typewriter correction fluid.
It was reproduced at the same size it was drawn, unlike his other work, which was usually drawn larger and shrunk down, which hides defects in the art.
Spiegelman has published articles promoting a greater knowledge of his medium's history. Spiegelman stated, "without Binky Brown , there would be no Maus ".
Spiegelman's work as cartoonist and editor had long been known and respected in the comics community, but the media attention after the first volume's publication in was unexpected.
Maus proved difficult to classify to a genre,  and has been called biography, fiction, autobiography, history, and memoir. An editor responded, "Let's go out to Spiegelman's house and if a giant mouse answers the door, we'll move it to the nonfiction side of the list!
Maus ranked highly on comics and literature lists. The Comics Journal called it the fourth greatest comics work of the 20th century,  and Wizard placed it first on their list of Greatest Graphic Novels.
Early installments of Maus that appeared in Raw inspired the young Chris Ware to "try to do comics that had a 'serious' tone to them".
In , cartoonist Ted Rall had an article published in The Village Voice criticizing Spiegelman's prominence and influence in the New York cartooning community.
Hellman followed up by posting fake responses from New York magazine editors and art directors.
A cottage industry of academic research has built up around Maus ,  and schools have frequently used it as course material in a range of fields: history, dysfunctional family psychology,  language arts, and social studies.
Few approached Maus who were familiar with comics, largely because of the lack of an academic comics tradition— Maus tended to be approached as Holocaust history or from a film or literary perspective.
According to writer Arie Kaplan, some Holocaust survivors objected to Spiegelman making a comic book out of their tragedy. Harvey argued that Spiegelman's animal metaphor threatened "to erode [ Maus ' s] moral underpinnings",  and played "directly into [the Nazis'] racist vision".
Commentators such as Peter Obst and Lawrence Weschler expressed concern over the Poles' depiction as pigs,  which reviewer Marek Kohn saw as an ethnic slur  and The Norton Anthology of American Literature called "a calculated insult".
Literary critic Walter Ben Michaels found Spiegelman's racial divisions "counterfactual". To Michaels, Maus seems to gloss over the racial inequality that has plagued the history of the U.
Other critics, such as Bart Beaty, objected to what they saw as the work's fatalism. Scholar Paul Buhle asserted, "More than a few readers have described [ Maus ] as the most compelling of any [Holocaust] depiction, perhaps because only the caricatured quality of comic art is equal to the seeming unreality of an experience beyond all reason.
The book reproduced every page and line of dialogue from the French translation of Maus. Spiegelman's French publisher, Flammarion , had the Belgian publisher destroy all copies under charges of copyright violation.
Moss, Joshua Louis University of Texas Press. From Wikipedia, the free encyclopedia. This article is about the graphic novel. For other uses, see Maus disambiguation.
This spelling was chosen for Maus as it was deemed the easiest spelling for English speakers to pronounce correctly. The German version of his name was "Wilhelm" or "Wolf" for short , and he became William when he moved to the U.
Her name became Anna when she and Vladek arrived in the U. Abell, Catharine Documentary Graphic Novels and Social Realism. Peter Lang.
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Review of clinical data with CAR T cells in hematologic malignancies. Future outlook. Article Navigation. Maus , Marcela V. This Site.
Google Scholar. Stephan A. Grupp , Stephan A. David L. Porter , David L. Carl H. June Carl H. Blood 17 : — Article history Submitted:.
Connected Content. This is a companion to: Advances in the treatment of hematologic malignancies using immunoconjugates.
This is a companion to: Immunotoxins for leukemia. Cite Icon Cite. Figure 1. View large Download PPT.
Figure 2. Table 1 CAR T-cell trials in hematologic malignancies. Signaling domain. Other genes. Cytokine support. Number of patients.
Persistence peak and duration. View Large. Gene transfer. CAR signaling domain. The online version of this article contains a data supplement.
The authors thank Anne Chew and Bruce Levine for constructive comments. Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy.
Search ADS. Combinational targeting offsets antigen escape and enhances effector functions of adoptively transferred T cells in glioblastoma.
Anti-CDchimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia. Receptor affinity and extracellular domain modifications affect tumor recognition by ROR1-specific chimeric antigen receptor T cells.
T cell activation by recombinant FcepsilonRI gamma-chain immune receptors: an extracellular spacer domain impairs antigen-dependent T cell activation but not antigen recognition.
Adoptive T cell transfer for cancer immunotherapy in the era of synthetic biology. Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system.
Stable gene transfer and expression in human primary T cells by the Sleeping Beauty transposon system. Sleeping beauty system to redirect T-cell specificity for human applications.
Decade-long safety and function of retroviral-modified chimeric antigen receptor T cells. Sci Transl Med. Lentiviral vector common integration sites in preclinical models and a clinical trial reflect a benign integration bias and not oncogenic selection.
IL-7 and IL allow the generation of suicide gene-modified alloreactive self-renewing central memory human T lymphocytes. CDspecific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and BB domains: pilot clinical trial results.
CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients.
Derivation of human T lymphocytes from cord blood and peripheral blood with antiviral and antileukemic specificity from a single culture as protection against infection and relapse after stem cell transplantation.
Infusion of donor-derived CDredirected virus-specific T cells for B-cell malignancies relapsed after allogeneic stem cell transplant: a phase 1 study.
T cell immunotherapy: optimizing trial design. Paper presented at the Scientific Symposium, September , Bethesda, MD. Manufacture of clinical-grade CDspecific T cells stably expressing chimeric antigen receptor using Sleeping Beauty system and artificial antigen presenting cells.
Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells.
Donor-derived CDtargeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation.
Safety and persistence of adoptively transferred autologous CDtargeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias.
Treatment of chronic lymphocytic leukemia with genetically targeted autologous T cells: case report of an unforeseen adverse event in a phase I clinical trial.
CDtargeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia.
T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia. Chimeric receptors containing CD signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo.
HLH Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Highly elevated ferritin levels and the diagnosis of hemophagocytic lymphohistiocytosis.
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